Mamoru Watanabe Selected Research

Colitis

12/2022	Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice.
1/2022	Transplantation of intestinal organoids into a mouse model of colitis.
1/2022	Activated Mucosal-associated Invariant T Cells Have a Pathogenic Role in a Murine Model of Inflammatory Bowel Disease.
1/2021	Oral administration of D-serine prevents the onset and progression of colitis in mice.
1/2021	5-aminosalicylate-intolerant patients are at increased risk of colectomy for ulcerative colitis.
4/2018	Complete mucosal healing of distal lesions induced by twice-daily budesonide 2-mg foam promoted clinical remission of mild-to-moderate ulcerative colitis with distal active inflammation: double-blind, randomized study.
1/2018	Contribution of ATOH1+ Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium.
1/2018	Asian Organization for Crohn's and Colitis and Asian Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti-tumor necrosis factor treatment. Part 1: Risk assessment.
1/2018	B cell activation in the cecal patches during the development of an experimental colitis model.
1/2018	Asian Organization for Crohn's and Colitis and Asia Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti-tumor necrosis factor treatment. Part 1: risk assessment.

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Mamoru Watanabe Research Topics

Disease

56	Ulcerative Colitis 03/2022 - 07/2003
46	Colitis 12/2022 - 02/2003
45	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022 - 11/2002
44	Crohn Disease (Crohn's Disease) 12/2022 - 12/2002
35	Infections 03/2021 - 09/2003
25	Inflammation (Inflammations) 12/2022 - 07/2002
24	Neoplasms (Cancer) 11/2022 - 07/2002
18	Chronic Hepatitis C 05/2019 - 07/2002
8	Colonic Neoplasms (Colon Cancer) 07/2021 - 10/2005
8	Hepatocellular Carcinoma (Hepatoma) 10/2020 - 01/2004
7	Carcinogenesis 12/2019 - 07/2003
6	Tuberculosis (Tuberculoses) 08/2021 - 05/2013
6	Liver Cirrhosis (Hepatic Cirrhosis) 10/2020 - 04/2004
6	Ulcer 03/2020 - 01/2004
6	Fibrosis (Cirrhosis) 11/2017 - 06/2010
6	Hepatitis C 07/2016 - 06/2003
5	Hemorrhage 01/2022 - 12/2015
5	Necrosis 07/2021 - 09/2016
5	Intestinal Diseases (Diseases, Intestinal) 01/2020 - 12/2011
5	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 07/2003
5	Liver Diseases (Liver Disease) 06/2019 - 04/2004
4	Disease Progression 04/2022 - 05/2016
4	Colitis-Associated Neoplasms 03/2021 - 04/2009
4	Chronic Hepatitis (Chronic Active Hepatitis) 04/2020 - 04/2004
4	Anemia 10/2017 - 11/2010
3	Herpes Zoster 03/2022 - 02/2013
3	Hemolytic Anemia 10/2017 - 11/2010
3	Virus Diseases (Viral Diseases) 06/2015 - 12/2007
3	Pain (Aches) 08/2014 - 08/2006
3	Neoplasm Metastasis (Metastasis) 01/2013 - 10/2005
3	Wasting Syndrome (Wasting Disease) 04/2007 - 10/2003
2	Adenocarcinoma 11/2022 - 03/2018
2	Abscess 01/2022 - 09/2006
2	Injection Site Reaction 10/2021 - 01/2009
2	Wounds and Injuries (Trauma) 01/2021 - 01/2020

Drug/Important Bio-Agent (IBA)

18	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2021 - 06/2003
17	Ribavirin (Virazole)FDA LinkGeneric 04/2020 - 04/2004
17	InterferonsIBA 11/2017 - 04/2004
16	Antiviral Agents (Antivirals)IBA 10/2020 - 04/2004
14	Adalimumab (Humira)FDA Link 01/2022 - 03/2012
13	Interleukin-7 (Interleukin 7)IBA 11/2013 - 03/2003
12	Proteins (Proteins, Gene)FDA Link 12/2022 - 01/2005
12	CytokinesIBA 10/2021 - 12/2002
11	Infliximab (Remicade)FDA Link 08/2021 - 02/2011
9	Pharmaceutical PreparationsIBA 04/2022 - 07/2002
9	Monoclonal AntibodiesIBA 07/2021 - 02/2003
8	vedolizumabIBA 01/2022 - 03/2017
8	Adrenal Cortex Hormones (Corticosteroids)IBA 12/2021 - 01/2007
8	InterleukinsIBA 01/2016 - 06/2003
6	Dextran SulfateIBA 12/2022 - 08/2003
6	Mesalamine (Mesalazine)FDA LinkGeneric 01/2022 - 07/2013
6	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2017
6	AntibodiesIBA 04/2020 - 09/2003
5	Immunologic Factors (Immunomodulators)IBA 01/2022 - 03/2011
5	Immunosuppressive Agents (Immunosuppressants)IBA 01/2021 - 11/2002
5	2-mercaptopurineIBA 10/2019 - 05/2013
5	SteroidsIBA 07/2016 - 08/2006
5	Interferon-alpha (Interferon Alfa)IBA 03/2013 - 09/2005
5	RNA (Ribonucleic Acid)IBA 09/2011 - 09/2003
5	AntigensIBA 10/2005 - 01/2002
4	LigandsIBA 01/2022 - 10/2003
4	Leucine (L-Leucine)FDA Link 01/2022 - 01/2017
4	Glycoproteins (Glycoprotein)IBA 01/2022 - 01/2017
4	Tacrolimus (Prograf)FDA LinkGeneric 12/2021 - 02/2011
4	Anti-Bacterial Agents (Antibiotics)IBA 09/2021 - 09/2006
4	Interleukin-12 (IL 12)IBA 07/2021 - 12/2002
4	tofacitinibIBA 01/2021 - 01/2018
4	Budesonide (Pulmicort)FDA LinkGeneric 01/2020 - 01/2018
4	Inosine TriphosphataseIBA 10/2017 - 11/2010
4	Interleukin-6 (Interleukin 6)IBA 01/2016 - 01/2011
3	Amino Acids FDA Link 01/2021 - 06/2011
3	Biological ProductsIBA 01/2021 - 05/2005
3	Azathioprine (Imuran)FDA LinkGeneric 09/2019 - 11/2016
3	AlbuminsIBA 06/2019 - 09/2015
3	Capsules (Microcapsules)IBA 03/2019 - 01/2014
3	Dextrans (Dextran)FDA Link 01/2018 - 01/2005
3	Type II Tumor Necrosis Factor ReceptorsIBA 01/2016 - 04/2009
3	Immunoglobulin G (IgG)IBA 07/2015 - 08/2003
3	Interleukin-7 Receptors (Interleukin 7 Receptor)IBA 02/2011 - 08/2003
3	Cyclosporine (Ciclosporin)FDA LinkGeneric 02/2011 - 01/2004
3	Messenger RNA (mRNA)IBA 01/2011 - 01/2005
3	Interleukin-18 (Interleukin 18)IBA 08/2003 - 12/2002
2	NickelIBA 12/2022 - 01/2021
2	Janus Kinase 1IBA 03/2022 - 01/2021
2	GLPG0634IBA 03/2022 - 01/2021
2	OxazoloneIBA 01/2022 - 01/2018
2	AJM300IBA 01/2022 - 12/2015
2	Biosimilar PharmaceuticalsIBA 08/2021 - 10/2019
2	CT-P13IBA 08/2021 - 10/2019
2	Ustekinumab (CNTO 1275)FDA Link 07/2021 - 03/2017
2	Carrier Proteins (Binding Protein)IBA 10/2020 - 05/2019
2	C-Reactive ProteinIBA 01/2020 - 02/2014
2	Phosphotransferases (Kinase)IBA 12/2019 - 08/2010
2	Janus Kinase InhibitorsIBA 10/2019 - 04/2018

Therapy/Procedure

81	Therapeutics 03/2022 - 07/2003
6	Transplantation 01/2022 - 07/2002
5	Colectomy 01/2021 - 04/2005
4	Drug Therapy (Chemotherapy) 01/2016 - 02/2010
3	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2016 - 09/2005
2	Aftercare (After-Treatment) 01/2020 - 03/2015